Tuberal hypothalamic neurons secreting the satiety molecule Nesfatin-1 are critically involved in paradoxical (REM) sleep homeostasis.

The recently discovered Nesfatin-1 plays a role in appetite regulation as a satiety factor through hypothalamic leptin-independent mechanisms.Nesfatin-1 is co-expressed with Melanin-Concentrating Hormone (MCH) in neurons from the tuberal Egg Timer hypothalamic area (THA) which are recruited during sleep states, especially paradoxical sleep (PS).To

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Protein domain organisation: adding order

Abstract Background Domains are the building blocks of proteins.During evolution, they have been duplicated, fused and recombined, to produce proteins with novel structures and functions.Structural and genome-scale studies have shown that pairs or groups of domains observed together in a protein are almost always found in only one N to C terminal o

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